Rigelian fever

• Deadly disease first appearing late-13th century during forceable resettling of Kalar on Rigel VII (ENT Novel: Tower of Babel)
  • Appeared due to crowded, unsanitary conditions leading to heightened levels of viral cross-propagation and mutation (ENT Novel: Tower of Babel)
• If left untreated, one of the deadliest known contagions (ENT: "Cold Station 12")
• Cure first developed 1370 (Tower of Babel Annotations)
  • Treatment regimen derived from ryetalyn-based compound (Tower of Babel Annotations; TOS: "Requiem for Methusaleh"; TNG Novel: The Battle of Betazed)
• Betazoid vaccine developed on Betazed mid- to late 23rd century upon planetary exposure (TNG Novel: The Battle of Betazed)
  • Vaccine cannot be used on individuals below the age of six (TNG Novel: The Battle of Betazed)
  • Vaccine essentially eradicated Rigelian fever on Betazed outside wild animals (TNG Novel: The Battle of Betazed)
  • Unstated if vaccine is effective or not on other species, but likely so given usual Trek medical functionality