Life of unknown origin
- Life forms with no explicitly specified planet of origin
Animal
- Circassian hellcat (VOY Novel: Mosaic)
- Vicious and/or short-tempered animal (VOY Novel: Mosaic)
- Hupyrian beetle (DS9: "Family Business", "Ferengi Love Songs"; DS9 Novel: Mission Gamma: Cathedral)
- Jacinnan racing cat (TNG Novel: The Buried Age)
- Noted for its speed (TNG Novel: The Buried Age)
- Javathian oyster (VAN Novel: Summon the Thunder)
- Edible by Chelons (VAN Novel: Summon the Thunder)
- Jebret (DS9 Novel: The 34th Rule)
- Small animal (DS9 Novel: The 34th Rule)
- Looci hen (VOY Novel: Mosaic)
- Nesting bird known to Kazon (VOY Novel: Mosaic)
- Native to Delta Quadrant (VOY Novel: Mosaic)
- Kryonian tiger (TNG Novel: A Time to Kill)
- Osmotic eel (ENT: "Broken Bow", "Minefield", "Marauders", "Exile", "The Council", "Countdown", "Home")
- Seemingly consumes microorganisms and parasites in the blood symbiotically, while halting bloodflow, consuming small amounts of blood in the process (ENT: "Broken Bow", "Minefield", "Countdown"; ENT Novel: Uncertain Logic)
- Plorgha (VAN Novel: Reap the Whirlwind)
- Creature noted idiomatically for sweating (VAN Novel: Reap the Whirlwind)
- Possibly native to Denobula
- Rintannan (DS9 Novel: Mission Gamma: Twilight)
- Native to Gamma Quadrant planet (DS9 Novel: Mission Gamma: Twilight)
- Resembling more rigid, spheroid jellyfish (DS9 Novel: Mission Gamma: Twilight)
- Communal chameleon predator species, forming larger structures to blend into local landscape (DS9 Novel: Mission Gamma: Twilight)
- Slijm (VAN Novel: Summon the Thunder)
- Appearing to be a cross between a dog and a walrus (VAN Novel: Summon the Thunder)
- Covered in blubber coated in smooth, brown fur (VAN Novel: Summon the Thunder)
- Domesticated (VAN Novel: Summon the Thunder)
- Possibly from the Zakdorn homeworld (VAN Novel: Summon the Thunder)
- Talarian hook spider (TNG: "Realm of Fear"; DS9 Novel: Mission Gamma: Cathedral)
- Presumably native to somewhere in Talarian space
- Toskanar dog (VOY Novel: Mosaic)
- Treni cat (DS9 Novel: The 34th Rule)
- Small animal (DS9 Novel: The 34th Rule)
- Tumodian lamprey (ENT Novel: Uncertain Logic)
- Feeds on contaminants in blood symbiotically (ENT Novel: Uncertain Logic)
- Can serve as a natural form of hemodialysis as a result (ENT Novel: Uncertain Logic)
- Feeds on contaminants in blood symbiotically (ENT Novel: Uncertain Logic)
- Vayan hornfly (DS9 Novel: Mission Gamma: Cathedral)
- Vghlar beetle (ENT Novel: Live by the Code)
- Can serve as natural vitamin supplement for humanoids (ENT Novel: Live by the Code)
- Vicarian razorback (DS9: "The Die is Cast"; DS9 Novel: Avatar, Book Two, Mission Gamma: This Gray Spirit)
- Native to a world near Bajoran and Cardassian space
- Yurhaath (ENT Novel: Live by the Code)
- Bird-like species known to the Hurraait (ENT Novel: Live by the Code)
Plant
- Diomedian scarlet moss (TNG Novel: The Battle of Betazed)
- Draebidium calimus (TNG Novel: The Battle of Betazed)
- Flower similar to violets (TNG Novel: The Battle of Betazed)
- Kelodan rose (VOY Short Story: "Closure")
- Native to Delta Quadrant in or near Talax (VOY Short Story: "Closure")
- Leola (VOY)
- Rare plant found across various Delta Quadrant worlds in vicinity of Talax
- Root is considered a delicacy among Talaxians, other nearby cultures
- Shendurian stingvine (ENT Novel: Uncertain Logic)
- Bulbous yellow-green plant seemingly a blend of vine and cactus (ENT Novel: Uncertain Logic)
- Extremely pungent, sweet aroma (ENT Novel: Uncertain Logic)