Donna O'Neill
- Full Name: Donna "D.O." O'Neill
- Species: Human
- Gender: Female
- By 2155: Lieutenant, gamma shift watch officer, Earth Starfleet; Enterprise NX-01 (ENT Novel: The Good That Men Do, Kobayashi Maru, Beneath the Raptor's Wing)
- March 2156: Lieutenant, acting executive officer, Earth Starfleet; Enterprise NX-01 (ENT Novel: Beneath the Raptor's Wing, To Brave the Storm)